刘金平

作者: 时间:2021-07-02 点击数:

姓名

刘金平

职称

教授;博士导师

WeChat Image_20200616123512

办公地点

吉林大学基础医学院125室

办公电话

0431-85619803

邮箱

liujp@jlu.edu.cn

教育背景

1993-1997 学士 药物制剂 药学系 沈阳药科大学

1999-2002 硕士 药物化学 基础医学院 原白求恩医科大学

2002-2005 博士 天然药物化学 中药学院 沈阳药科大学

工作经历

1997-1999 助教 基础医学院 原白求恩医科大学

2002-2006 讲师 药学院 吉林大学

2006-2008 博士后 生物学博士后流动站 吉林大学

2008-2014 副教授、硕士生导师 药学院 吉林大学

2013-2014 访问学者 医学院 哈佛大学 美国

2014-至今 教授 药学院 吉林大学

2015-至今 副主任 人参创新药物开发国家地方联合工程研究中心

2017-至今 副主任 吉林大学天然药物研究中心

2017-至今 博士生导师 药学院 吉林大学

2018-至今 主任 吉林省人参(西洋参)创新药物开发工程研究中心

主讲课程

药物设计学;新药设计

研究领域

天然产物;中药;药效物质基础;药理作用;创新药物

科研成果

发表SCI科研论文75篇,其中第一作者或通讯作者47篇。发表中文文章150余篇。获授权发明专利36项。出版著作7部,其中副主编4部,编者3部。

SCI文章:

1.Zhou B S, Liu J T, Wang Y R,Wu F L, Wang C X, Wang C Z, Liu, J P, Li P Y. Protective Effect of Ethyl Rosmarinate against Ulcerative Colitis in Mice Based on Untargeted MetabolomicsInt. J Mol Sci. 2022;23(3):1256.

2.Liu J L, Liu Y H, Yu H, Lin H Q, Zhang Y, Hsu ACY, Zhang M M, Sun W, Wang F, Li P Y, Liu, J P. Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity. Biomedicine & Pharmacotherapy. 2021, 133:111050.

3.Liu Y H, Wang Z Y, Wang C X, Si H R, Yu H, Li L, Fu S Z, Tan L Y, Li P Y, Liu, J P, Zhao Y. Comprehensive phytochemical analysis and sedative-hypnotic activity of two Acanthopanax species leaves. Food & function. 2021;12(5):2292-2311.

4.Liu J L, Liu Y H, Lin H Q, Zhou B S, Yu H, Li L, Wang C X, Li X Y, Li P Y, Liu J P, Hao X H. The effect of ginsenoside Rg5, isolated from black ginseng, on heart failure in zebrafish based on untargeted metabolomics. Journal of Functional Foods. 2021, 76:104325.

5.WANG, C. Z., YUAN, Y. Z., PAN, H., HSU, A. C. Y., CHEN, J. L., LIU, J. P., LI, P. Y. & WANG, F. 2020. Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics. International Journal of Molecular Sciences, 21, 19.

6.FU, T. H., LIU, X. F., LIU, J. P., CAI, E. B., ZHAO, Y., LI, H. J., ZHANG, L. X., LI, P. Y. & GAO, Y. G. 2020. alpha-Mangostin exhibits antidepressant-like effects mediated by the modification of GABAergic, serotonergic and dopaminergic systems. Natural Product Research, 34, 868-871.

7.Zhang Y, Yu H, Fu S Z, Tan L Y, Liu J L, Zhou B S, Li L, Liu Y H, Wang C Z, Li P Y, Liu, J P. Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol. Molecules. 2021, 26(4):780

8.WANG, C., YUAN, Y., PAN, H., HSU, A. C. Y., CHEN, J., LIU, J., LI, P. & WANG, F. 2020. Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics. International journal of molecular sciences, 21, 2577.

9.TAN, J., LIU, J. L., WANG, H., ZHANG, Y., LIN, H. Q., WANG, N. Y., SI, H. R., ZHANG, Y. T., LIU, J. P., LI, P. Y. & SUN, K. 2020. Identification of blood-activating components from Xueshuan Xinmaining Tablet based on the spectrum-effect relationship and network pharmacology analysis. Rsc Advances, 10, 9587-9600.

10.YANG, N., WANG, H., LIN, O. Q., LIU, J. L., ZHOU, B. S., CHEN, X. L., WANG, C. Z., LIU, J. P. & LI, P. Y. 2020. Comprehensive metabolomics analysis based on UPLC-Q/TOF-MSE and the anti-COPD effect of different parts of Celastrus orbiculatus Thunb. Rsc Advances, 10, 8396-8420.

11.WANG, C. Z., DONG, Q. H., WU, F. L., LI, Z., LI, P. Y., LIU, J. P. & WANG, F. 2020. A new alkynol compound from Platycodins folium and its cytotoxicity. Natural Product Research, 7.

12.LIN, H. Q., ZHU, H. L., TAN, J., WANG, H., WANG, Z. Y., LI, P. Y., ZHAO, C. F. & LIU, J. P. 2019. Comparative Analysis of Chemical Constituents of Moringa oleifera Leaves from China and India by Ultra-Performance Liquid Chromatography Coupled with Quadrupole-Time-Of-Flight Mass Spectrometry. Molecules, 24, 25.

13.QI, Z., WANG, Z., ZHOU, B., FU, S., HONG, T., LI, P. & LIU, J. 2020. A new ocotillol-type ginsenoside from stems and leaves ofPanax quinquefoliumL. and its anti-oxidative effect on hydrogen peroxide exposed A549 cells. Natural Product Research, 34, 2474-2481.

14.LIN, H. Q., ZHU, H. L., TAN, J., WANG, H., DONG, Q. G., WU, F. L., LIU, Y. H., LI, P. Y. & LIU, J. P. 2019. Non-Targeted Metabolomic Analysis of Methanolic Extracts of Wild-Simulated and Field-Grown American Ginseng. Molecules, 24, 25.

15.QI, Z., LI, Z., GUAN, X. W., WANG, C. Z., WANG, F., LI, P. Y. & LIU, J. P. 2019. Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica. Molecules, 24, 13.

16.WANG, C. Z., LIN, H. Q., YANG, N., WANG, H., ZHAO, Y., LI, P. Y., LIU, J. P. & WANG, F. 2019. Effects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics. Molecules, 24, 20.

17.LIN, H. Q., ZHU, H. L., TAN, J., WANG, C. Z., DONG, Q. H., WU, F. L., WANG, H., LIU, J. L., LI, P. Y. & LIU, J. P. 2019. Comprehensive Investigation on Metabolites of Wild-Simulated American Ginseng Root Based on Ultra-High-Performance Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry. Journal of agricultural and food chemistry, 67, 5801-5819.

18.QI, Z., LI, W., TAN, J., WANG, C. Z., LIN, H. Q., ZHOU, B. S., LIU, J. P. & LI, P. Y. 2019. Effect of ginsenoside Rh-2 on renal apoptosis in cisplatin-induced nephrotoxicity in vivo. Phytomedicine, 61, 14.

19.ZHANG, K., LIU, Y., WANG, C. Z., LI, J. N., XIONG, L. X., WANG, Z. Z., LIU, J. P. & LI, P. Y. 2019. Evaluation of the gastroprotective effects of (20S)-ginsenoside Rg3 on gastric ulcer models in mice. Journal of Ginseng Research, 43, 550-561.

20.WU, D., WANG, H., TAN, J., WANG, C., LIN, H., ZHU, H., LIU, J., LI, P. & YIN, J. 2019. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules, 24.

21.ZHU, H. L., LIU, J. L., LIN, H. Q., ZHANG, Y., YANG, N., ZHOU, B. S., WANG, Z. Y., HSU, A. C. Y., LIU, J. P. & LI, P. Y. 2019. UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng. Rsc Advances, 9, 38658-38668.

22.QI, Z., CHEN, L. X., LI, Z., SHAO, Z. J., QI, Y. L., GAO, K., LIU, S. X., SUN, Y. S., LI, P. Y. & LIU, J. P. 2019c. Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study. International journal of molecular sciences, 20, 836.

23.YIN, Y. X., ZHANG, Y. G., LI, H. J., ZHAO, Y., CAI, E. B., ZHU, H. Y., LI, P. Y. & LIU, J. P. 2019. Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice. Biomedicine & Pharmacotherapy, 109, 493-502.

24.ZHU, H. L., LIN, H. Q., TAN, J., WANG, C. Z., QANG, H., WU, F. L., DONG, Q. H., LIU, Y. H., LI, P. Y. & LIU, J. P. 2019. UPLC-QTOF/MS-Based Nontargeted Metabolomic Analysis of Mountain- and Garden-Cultivated Ginseng of Different Ages in Northeast China. Molecules, 24, 1-24.

25.BIAN, X. B., LIU, X. F., LIU, J. P., ZHAO, Y., LI, H. J., ZHANG, L. X., LI, P. Y. & GAO, Y. G. 2019. Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-B and activating Nrf2/HO-1 signaling pathways. Journal of the Science of Food and Agriculture, 99, 3283-3290.

26.RAN, N., PANG, Z. Q., GUAN, X. W., WANG, G. Q., LIU, J. P., LI, P. Y., ZHENG, J. T. & WANG, F. 2019. Therapeutic Effect and Mechanism Study of Rhodiola wallichiana var. cholaensis Injection to Acute Blood Stasis Using Metabolomics Based on UPLC-Q/TOF-MS. Evidence-Based Complementary and Alternative Medicine, 2019, 20.

27.BIAN, X. B., WANG, S. J., LIU, J. P., ZHAO, Y., LI, H. J., ZHANG, L. X. & LI, P. Y. 2019. Hepatoprotective effect of chiisanoside against acetaminophen-induced acute liver injury in mice. Natural Product Research, 33, 2704-2707.

28.ZHANG, Q. H., LI, X. Z., HAN, L., LI, P. Y. & LU, D. 2018. Determination of Sophorabioside in Rat Plasma by UPLC-MS/MS and its Application to a Pharmacokinetic Study. Journal of Chromatographic Science, 56, 154-159.

29.BIAN, X. B., LIU, X. F., LIU, J. P., ZHAO, Y., LI, H. J., CAI, E. B., LI, P. Y. & GAO, Y. G. 2018. Study on antidepressant activity of chiisanoside in mice. International Immunopharmacology, 57, 33-42.

30.FU, T. H., WANG, S. J., LIU, J. P., CAI, E. B., LI, H. J., LI, P. Y. & ZHAO, Y. 2018. Protective effects of α-mangostin against acetaminophen-induced acute liver injury in mice. European journal of pharmacology, 827, 173-180.

31.YIN, Y. X., LIU, X. F., LIU, J. P., CAI, E. B., ZHU, H. Y., LI, H. J., ZHANG, L. X., LI, P. Y. & ZHAO, Y. 2018. Beta-sitosterol and its derivatives repress lipopolysaccharide/D-galactosamine-induced acute hepatic injury by inhibiting the oxidation and inflammation in mice. Bioorganic & Medicinal Chemistry Letters, 28, 1525-1533.

32.WANG, W. D., WANG, S. J., LIU, J. P., CAI, E. B., ZHU, H. Y., HE, Z. M., GAO, Y. G., LI, P. Y. & ZHAO, Y. 2018. Sesquiterpenoids from the root of Panax Ginseng protect CCl4-induced acute liver injury by anti-inflammatory and anti-oxidative capabilities in mice. Biomedicine & Pharmacotherapy, 102, 412-419.

33.WANG, W. D., ZHANG, Y. G., LI, H. J., ZHAO, Y., CAI, E. B., ZHU, H. Y., LI, P. Y. & LIU, J. P. 2018. Protective Effects of Sesquiterpenoids from the Root of Panax ginseng on Fulminant Liver Injury Induced by Lipopolysaccharide/dGalactosamine. Journal of agricultural and food chemistry, 66, 7758-7763.

34.WANG, Y. R., WANG, C. Z., LIN, H. Q., LIU, Y. H., LI, Y. M., ZHAO, Y., LI, P. Y. & LIU, J. P. 2018. Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis. Molecules, 23, 1525-1549.

35.TAN, J., WANG, C. Z., ZHU, H. L., ZHOU, B. S., XIONG, L. X., WANG, F., LI, P. Y. & LIU, J. P. 2018. Comprehensive Metabolomics Analysis of Xueshuan Xinmaining Tablet in Blood Stasis Model Rats Using UPLC-Q/TOF-MS. Molecules, 23, 16.

36.YIN, Y. X., LIU, X. F., LIU, J. P., CAI, E. B., ZHAO, Y., LI, H. J., ZHANG, L. X., LI, P. Y. & GAO, Y. G. 2018. The effect of beta-sitosterol and its derivatives on depression by the modification of 5-HT, DA and GABA-ergic systems in mice. Rsc Advances, 8, 671-680.

37.FU, T. H., LI, H. J., ZHAO, Y., CAI, E. B., ZHU, H. Y., LI, P. Y. & LIU, J. P. 2018. Hepatoprotective effect of alpha-mangostin against lipopolysaccharide/D-galactosamine-induced acute liver failure in mice. Biomedicine & Pharmacotherapy, 106, 896-901.

38.QI, Z., LI, Z., LI, W., LIU, Y., WANG, C., LIN, H., LIU, J. & LI, P. 2018. Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice. Molecules (Basel, Switzerland), 23, 3038.

39.WANG, W. D., LIU, X. F., LIU, J. P., CAI, E. B., ZHAO, Y., LI, H. J., ZHANG, L. X., LI, P. Y. & GAO, Y. G. 2018. Sesquiterpenoids from the Root of Panax ginseng Attenuates Lipopolysaccharide-lnduced Depressive-Like Behavior through the Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase B and Sirtuin Type 1/Nuclear Factor-kappa B Signaling Pathways. Journal of agricultural and food chemistry, 66, 265-271.

40.WANG, Z. Z., LIN, H. Q., ZHU, H. L., YANG, N., ZHOU, B. S., WANG, C. Z., LI, P. Y. & LIU, J. P. 2018. Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MSE. Molecules, 23, 15.

41.PANG, Z. Q., WANG, G. Q., WANG, C. Z., ZHANG, W. J., LIU, J. P. & WANG, F. 2018. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. Biomed Research International, 2018.

42.LIU, J. P., PANG, Z. Q., WANG, G. Q., GUAN, X. W., FANG, K. Y., WANG, Z. Y. & WANG, F. 2017. Advanced Role of Neutrophils in Common Respiratory Diseases. Journal of Immunology Research, 2017.

43.ZHANG, X. T., ZHANG, C., SAI, J. Y., LI, F., LIU, J. P., LI, Y. & WANG, F. 2015. Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r. Evidence-Based Complementary and Alternative Medicine, 2015.

44.WANG, C. Z., ZHANG, N. Q., WANG, Z. Z., QI, Z., ZHENG, B. Z., LI, P. Y. & LIU, J. P. 2017. Rapid characterization of chemical constituents of Platycodon grandiflorum and its adulterant Adenophora stricta by UPLC-QTOF-MS/MS. J. Mass Spectrom, 52, 643-656.

45.ZHANG, N. Q., WANG, C. Z., WANG, Z. Z., LI, Z., SAI, J. Y., MENG, Y., WANG, F., LI, P. Y. & LIU, J. P. 2017. Anti-myocardial ischaemic effect of pseudoginsenoside F11 by inhibiting expression of beta1-adrenoceptor in rats with coronary artery ligation. Journal of functional foods, 36, 224-232.

46.WANG, C. Z., ZHANG, N. Q., WANG, Z. Z., QI, Z., ZHU, H. L., ZHENG, B. Z., LI, P. Y. & LIU, J. P. 2017. Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China. Molecules, 22, 16.

47.BIAN, X., ZHAO, Y., GUO, X., ZHANG, L., LI, P., FU, T., WANG, W., YIN, Y., CHEN, G. & LIU, J. 2017. Chiisanoside, a triterpenoid saponin, exhibits anti-tumor activity by promoting apoptosis and inhibiting angiogenesis. Rsc Advances, 7, 41640-41650.

48.XIONG, L., QI, Z., ZHENG, B., LI, Z., WANG, F., LIU, J. & LI, P. 2017. Inhibitory Effect of Triterpenoids from Panax ginseng on Coagulation Factor X. Molecules, 22.

49.LI, W., ZHANG, X. R., XIN, Y. F., XUAN, Y. X., LIU, J. P., LI, P. Y. & ZHAO, Y. Q. 2016. Oral subchronic toxicity evaluation of a novel antitumor agent 25-methoxydammarane-3, 12, 20-triol from Panax notoginseng in Sprague-Dawley rats. Regulatory Toxicology and Pharmacology, 77, 240-251.

50.XIONG, L. X., XIE, J. S., SONG, C. X., LIU, J. P., ZHENG, J. T., LIU, C. G., ZHANG, X. T., LI, P. Y. & WANG, F. 2015. The Activation of Nrf2 and Its Downstream Regulated Genes Mediates the Antioxidative Activities of Xueshuan Xinmaining Tablet in Human Umbilical Vein Endothelial Cells. Evidence-Based Complementary and Alternative Medicine.

51.ZHENG, Q., LI, Z., LIU, J. P., HAN, L., ZHANG, N. Q., ZHANG, H., CHEN, J. L. & LI, P. Y. 2016. Two new dammarane-type triterpene sapogenins from Chinese red ginseng. Natural Product Research, 30, 95-99.

52.HAN, L., LI, Z., ZHENG, Q., LIU, J. P. & LI, P. Y. 2016. A new triterpenoid compound from stems and leaves of American ginseng. Natural Product Research, 30, 13-19.

53.HAN, L., LIN, M. Y., ZHENG, Q., LIU, H. Y., LIU, H. Y., DONG, G., LIU, J. P. & LI, P. Y. 2014. A new epimer of ocotillol from stems and leaves of American ginseng. Natural Product Research, 28, 935-939.

54.YAN, Z. W., LIU, J. P., LU, D., NARLAWAR, R., GROUNDWATER, P. & LI, P. Y. 2014. Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Natural Product Research, 28, 144-149.

55.HUO, J., WANG, H., HU, P., LI, P., LIU, J. & JIANG, J. 2013. Determination of pseudo-ginsenoside GQ in human plasma by high performance liquid chromatography-tandem mass spectrometry. Biomedical Chromatography, 27, 1701-1707.

56.QIU, N. N., HU, J., LIU, J. P., WANG, F. & LI, P. Y. 2013. Preparation and Cytotoxic Activities of Fatty Acid Derivatives of 20(S)-Protopanaxatriol. Letters in Drug Design & Discovery, 10, 402-409.

57.LIU, J. P., TIAN, X., LIU, H. Y., ZHANG, Q. H., LU, D., LI, P. Y. & ZHAO, C. F. 2013. Two novel dammarane-type compounds from the leaves and stems of Panax quinquefolium L. Journal of Asian Natural Products Research, 15, 974-978.

58.LIN, M. Y., GAO, H. M., LIU, J. P., HAN, L., ZHANG, Q. H. & LI, P. Y. 2013. UPLC-MS/MS determination and pharmacokinetic study of 26-OH-panaxadiol in rat plasma. Analytical methods, 5, 6656-6662.

59.GAO, H. M., LI, Z., LI, P. Y., LIN, M. Y., HAN, L., WANG, F. & LIU, J. P. 2013. Determination of Pseudoginsengenin DQ in rat plasma by UPLC-MS/MS and application of the method in a pharmacokinetic study. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 933, 1-7.

60.LU, D., LIU, J. P., ZHAO, W. J. & LI, P. Y. 2012. Chronic toxicity of ginsenoside Re on Sprague-Dawley rats. Journal of Ethnopharmacology, 144, 656-663.

61.LU, D., LI, P. Y. & LIU, J. P. 2012. Quinquenoside F6, a new triterpenoid saponin from the fruits of Panax quinquefolium L. Natural Product Research, 26, 1395-1401.

62.LIU, J. P., LU, D., NICHOLSON, R. C., ZHAO, W. J., LI, P. Y. & WANG, F. 2012. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: A 26-week intramuscular repeated administration study in rats. Food and Chemical Toxicology, 50, 3388-3396.

63.ZHAO, Y., LIU, J. P., LU, D., LI, P. Y. & ZHANG, L. X. 2012. Two new xanthones from the pericarp of Garcinia mangostana. Natural Product Research, 26, 61-65.

64.LIU, J. P., WANG, F., LI, P. Y. & LU, D. 2012. A new ocotillol-type triterpenoid saponin from red American ginseng. Natural Product Research, 26, 731-735.

65.LIU, J. P., LU, D. & LI, P. Y. 2012. A novel hexanordammarane glycoside from the leaves and stems of Panax quinquefolium L. Natural Product Research, 26, 744-748.

66.LIU, J. P., LU, D., NICHOLSON, R. C., LI, P. Y. & WANG, F. 2011. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: A 26-week intramuscular repeated administration study in Beagle dogs. Food and Chemical Toxicology, 49, 1718-1727.

67.LIU, J. P., LU, D. & LI, P. Y. 2011. Two new dammarane-type triterpene saponins from red American ginseng. Journal of Asian Natural Products Research, 13, 198-204.

68.LI, N., HUANG, Y., XIAO, W., LIU, J. P., LI, X. & LI, P. Y. 2011. Synthesis and Cytotoxic Activities of New Fatty Acid Esters of 20(S)-Protopanaxadiol. Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences, 66, 199-204.

69.ZHAO, Y., LIU, J. P., LU, D., LI, P. Y. & ZHANG, L. X. 2010. A new antioxidant xanthone from the pericarp of Garcinia mangostana Linn. Natural Product Research, 24, 1664-1670.

70.YAN, Z. W., LIU, J. P., LU, D., GROUNDWATER, P., HE, C. Y. & LI, P. Y. 2010. A new 3,4-seco-lupane-type triterpenoid from the pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms. Natural Product Research, 24, 1523-1527.

71.LU, D., LIU, J. P. & LI, P. Y. 2010. Dihydrophenanthrenes from the stems and leaves of Dioscorea nipponica Makino. Natural Product Research, 24, 1253-1257.

72.LU, D., LIU, J. P., LI, H. J. & LI, P. Y. 2010. Phenanthrene derivatives from the stems and leaves of Dioscorea nipponica Makino. Journal of Asian Natural Products Research, 12, 1-6.

73.YAN, Z. W., LIU, J. P., LU, D., XUE, J. F. & LI, P. Y. 2009. A new bile acid from the bile of Anser anser. Natural Product Research, 23, 1312-1315.

74.ZHAO, Y., LIU, J. P., LU, D. & LI, P. Y. 2007. A novel cycloartane triterpene glycoside from the seeds of Cassia sophera L. Natural Product Research, 21, 494-499.

75.LIU, J. P., LU, D., ZHAO, Y., LI, P. Y. & LI, X. 2007. A new semisynthetic ocotillol-type saponin and resuscitation of haemorrhagic shock. Journal of Asian Natural Products Research, 9, 103-113.

专利:

1.刘云鹤,李乐,付书正,王钟瑶,谭璐瑩,王彩霞,余慧,李卓俏,李平亚,刘金平,2021,美花风毛菊总倍半萜内酯及制备方法和其药物用途,CN113350390A

2.刘云鹤,李乐,付书正,王钟瑶,谭璐瑩,王彩霞,余慧,李卓俏,李平亚,刘金平,2021,菴闾中总香豆素及制备方法和其药物用途,CN113230294A

3.林红强,余慧,王彩霞,李乐,周柏松,付书正,刘云鹤,谭璐瑩,刘金平,李平亚,2021,林下山西洋参在制备治疗抗生素相关性腹泻药物中的应用,CN113384609A

4.吴福林,陈小玲,史大臻,司函瑞,李乐,付书正,余慧,刘金平,李平亚,2021,原人参三醇PPT在制备抗血栓药物中的应用,CN112190585A

5.陈小玲,冯浩,司函瑞,吴福林,李乐,付东兴,刘俊彤,赖思含,刘金平,李平亚,2021,一种原人参三醇的结晶和单晶及其制备方法,CN113214338A

6.吴福林, 李平亚, 刘金平, 王德恒, 郭文英 & 李英杰,2019,止痛化癥胶囊的HPLC指纹图谱检测方法,CN108445125B

7.李平亚,郑茜,刘金平,张楠琪,王振洲,朱海林,陈金銮,张浩,2015,(20S,25R)-达玛-20,25-环氧-3β,12β,26,24β-四醇及其提取方法及医药用途,CN104761609A

8.王放,郑敬彤,路艳娇,张超,王国强,熊凌锌,关雪娃,陈芳,王婷,刘金平,酸浆苦素P在制备治疗慢性阻塞性肺病的药物中的应用,ZL201510680304.1

9.韩柳,李平亚,刘金平,李卓,郑茜,2015,达玛-20S,25S-环氧-3β, 12β, 26-三醇及其提取方法和药物用途,CN104693262A

10.李平亚,苏航,刘海燕,董刚,李卓,陈金銮,田旭,张庆贺,刘金平,2013,拟人参皂苷元R1及其提取方法和其药物用途,CN103193847A

11.李平亚,林美妤,韩柳,郑茜,李卓,刘海宇,王翠竹,刘金平,2013,拟人参皂苷RT6及其提取方法和其药物用途,CN103193848A

12.李平亚,刘金平,2013,一种西洋参果提取物的用途,CN102988441A

13.郝秀华,任媛媛,张庆贺,林美妤,刘海宇,李平亚,卢丹,刘金平,2012,达玛-20S, 25R-环氧-3β, 12β, 26-三醇及其提取方法和其药物用途,CN102329360A

14.李平亚,刘金平,任媛媛,刘传贵,胡军会,杜秀娟,2011,24(R)-拟人参皂苷元DQ的制备方法及其药物用途,CN102050860A

15.钟方丽,李平亚,刘金平,卢丹,赵岩,王晓林,2011,林下参皂苷B及其提取方法和其药物用途,CN102050864A

16.李平亚,刘金平,田旭,刘传贵,朱继忠,李丰,2011,拟人参皂苷RT5的提取方法及其药物用途,CN102010456A

17.李平亚,刘金平,刘传贵,金立群,张广民,闫智力,迟小娟,2011,一种伪人参皂苷GQ用途,CN102008498A

18.李平亚,刘金平,卢丹,刘传贵,杜秀娟,李丰,2011,20(R)-拟人参皂苷F11及其提取方法和其药物用途,CN101967170A

19.李平亚,刘金平,卢丹,刘传贵,杜秀娟,李丰,2011,人参皂苷R10及其提取方法和其药物用途,CN101948497A

20.李平亚,刘金平,卢丹,刘传贵,杜秀娟,李丰,2011,拟人参皂苷G2及其提取方法和其药物用途,CN101948498A

21.李平亚,刘金平,卢丹,刘传贵,杜秀娟,李丰,2011,拟人参皂苷G1及其提取方法和其药物用途,CN101948499A

22.刘金平,李平亚,卢丹,李艳娇,2010,西洋参皂苷F5ab及其提取方法和药物用途,CN101928320A

23.李平亚,刘金平,卢丹,薛健飞,2010,gartanin化合物在制备治疗高血脂症药物中的应用,CN101869559A

24.卢丹,李平亚,刘金平,2010,西洋参皂苷F6及其提取方法及其医药用途,CN101863945A

25.刘金平,李平亚,卢丹,薛健飞,2009,一种榛子素及其提取方法和药物用途,CN101613340

26.李平亚,卢丹,刘金平,2009,一种调节血脂的药物组合物,CN101584685

27.李平亚,刘金平,卢丹,周明娟,2009,刺五加果提取物在制备治疗高血脂症药物中的应用,CN101584719

28.刘金平,李平亚,卢丹,薛健飞,2009,榛子素B及其提取方法和其药物用途,CN101550125

29.卢丹,李平亚,刘金平,李海军,2009,5-羟甲基糠醛缩-5-糠醛甲醇及其制备方法及其医药用途,CN101544624

30.卢丹,李平亚,刘金平,李海军,2009,二缩(5-羟甲基糠醛)及其合成方法及其医药用途,CN101544654

31.李平亚,刘金平,卢丹,杜秀娟,2009,拟人参皂苷F11的医药用途,CN101524358

32.李平亚,刘金平,2009,拟人参皂苷F11的半合成方法,CN101519419

33.李平亚,卢丹,卢爱萍,刘金平,杜秀娟,2008,模拟移动床色谱拆分20(S)和20(R)-人参皂苷Rg3对映体,CN101230080

34.李平亚,刘金平,2005,伪人参皂苷-Pdq及其半合成方法和其药物用途,CN1706862

35.李平亚,赵文杰,刘金平,2004,人参果三醇组皂苷提取物及其提取、精制方法及其医药用途,CN1537863

36.李平亚,刘金平,卢丹,2004,西洋参果总皂苷提取物及其提取、精制方法及其医药用途,CN1482136

著作:

1.李平亚, 赵春芳, 刘金平. 2006. 猕猴桃的化学成分和生物活性研究进展, 吉林科学技术出版社.

2.张钧田, 李平亚, 卢丹, 刘金平. 2006. The Chemistry, Metabolism and Biological Activities of Ginseng, 化学工业出版社.

3.张钧田, 李平亚, 卢丹, 刘金平. 2008. 人参冠百草—人参化学、生物学活性和药代动力学研究进展, 化学工业出版社.

4.张辉, 李平亚, 冯家. 2010. 人参的功效与科学服用, 吉林出版集团有限责任公司.

5.李平亚, 刘金平, 卢丹. 2012. 人参皂苷 NMR 标准图谱, 化学工业出版社.

6.李平亚, 刘金平, 2017. 人参营养成分及功能因子, 化学工业出版社。

7.李平亚, 刘金平, 冯浩, 2019. 止痛化癥胶囊——药学·药效学·临床研究, 化学工业出版社.

8.杨洪军, 徐浩, 李平亚, 刘金平. 2020, 血脉双治-血栓心脉宁片现代研究, 人民卫生出版社.

9.李平亚, 刘金平. 2020, Ginseng Nutritional Components and Functional Factors, 斯普林格出版社.

版权所有:药学院

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